btov Partners, HV Holtzbrinck Ventures and HTGF invest in Real World Evidence and Patient-Reported Outcomes: 5 million euros for heartbeat medical

October 5, 2020

  • New standards for care management are set by connecting and utilising clinical data alongside data tracking patient-provided perspectives on their health status over time
  • Fundamental trend in health care: Patient-Reported Outcome Measures (PROMS) and Real World Evidence (RWE)
  • Over 200 hospital teams, registries and research institutions have registered to use the platform registered as a CE-marked medical device

The digital health start-up heartbeat medical has closed a Series A financing round with a volume of 5 million euros. The funds will be used to support organisational development and the expansion of capabilities of skills in the field of data analysis.

There is a great need for better data in quality assurance, measurement of treatment outcomes and medical research. This is where heartbeat medical steps in with its novel digital solutions. With its software, the start-up makes it possible for longitudinal patient-reported data to play an important role in their care management.

For the first time, Patient-Reported Outcome Measures (PROMs) are systematically linked to clinical data to improve treatment and research. In this way, clinical and scientific knowledge can be gained from routine clinical data (Real World Evidence, RWE). Scientifically well-founded and developed together with medical staff, heartbeat medical enables numerous medical departments to better manage care as well as to evaluate products and therapies using Real World Evidence.

The financing round is led by new investor btov Partners and existing investor HV Holtzbrinck Ventures. In addition, High-Tech Gründerfonds (HTGF) is increasing its holdings. After successful establishment in the German market and several years of proof of feasibility in regular clinical operation, heartbeat medical is aiming to expand the market leadership of its platform, classified as a medical device, in care management through PROMs.

In addition, the investment is to be used to further develop the current range of services. At present, more than 200 departments, registries and research projects are already under contract, which has enabled more than 150,000 patients to receive comprehensive support in their treatment. While these patients particularly benefit from the intuitive and personalised user interface, the medical staff is supported by a high degree of automation and intuitive data presentation.

The health care system is experiencing a fundamental change in terms of how we understand the success of treatment The improvements in the quality of life actually felt by patients through conservative, surgical and drug treatments are becoming comparable to purely clinical data as a basis for decision-making. Reliably collected, representative and high-quality health data are the basis for subsequent innovations and improvements.

Yannik Schreckenberger, managing director of heartbeat medical

With its data-driven approach, heartbeat has the best chance of becoming a central provider for improvements in clinical treatments and processes as well as drug development. In doing so, heartbeat medical benefits from global regulatory developments that accelerate patient-centered healthcare.

Jan-Hendrik Bürk, Principal at btov

About heartbeat medical
heartbeat medical is a leader in the collection and analysis of Patient-Reported Outcome Data (PROMs) and their linkage to clinical observations and embedding in treatments. Founded in 2014, the 40-strong team works from Berlin, Cologne and London on product development and support for over 200 hospital departments, registries and research projects. The Patient Reported Outcomes data are collected directly from patients in the form of standardised questionnaires and offer insights into the individually perceived treatment effects. Automatically linked to clinical data, a data-based foundation for decisions on medical and economic issues is thus created. heartbeat medical‘s platform, which is approved as a medical device, is already being used in a variety of ways for therapies and research as well as for the evaluation of medical components in regulatory procedures.
Further information is available at

Moritz Neubauer
heartbeat medical
Phone: +49 178 5208 707

About btov Partners
btov Partners, founded in 2000, is a European venture capital firm founded and financed by serial entrepreneurs and business angels, focusing on digital and industrial technology companies. btov manages its own institutional funds, partner funds and provides access to direct investment for private investors and family offices, with some of Europe‘s best-known investors as its advisors and co-investors. The company, with offices in Berlin, Munich, St. Gallen and Luxembourg, manages assets of €420 million in its three business divisions and screens over 3,000 investment opportunities annually. The most renowned investments include Data Artisans, Blacklane, DeepL, Facebook, Foodspring, ORCAM, Raisin, SumUp, Volocopter and XING.
Further information is available at

Virgile Dutrannoy
btov Partners GmbH
Phone: +49 30 346 558 423

About HV Holtzbrinck Ventures
HV Holtzbrinck Ventures has invested in internet and technology companies since 2000. HV is one of the most successful and financially strongest early-stage and growth investors in Europe. More than € 1 billion have been raised in multiple generations of funds. HV has invested in more than 185 companies, including Zalando, Delivery Hero, FlixMobility, SumUp and Scalable Capital. HV supports start-ups with capital between € 500,000 and € 50 million. This makes HV one of the few venture capitalists in Europe that can finance start-ups through all growth phases.
Further information is available

Felix Klühr
HV Holtzbrinck Ventures

About High-Tech Gründerfonds
The seed investor High-Tech Gründerfonds (HTGF) finances technology start-ups with high potential for growth. With a volume of around 900 million euros spread over three funds and an international partner network, the HTGF has supported almost 600 start-ups since 2005. Its team of experienced investment managers and start-up experts supports the young companies with know-how, entrepreneurial spirit and passion. The focus is on high-tech start-ups in the fields of digital tech, industrial tech, life sciences, chemistry and related business areas. To date, external investors have invested more than 2.6 billion euros in the HTGF portfolio in more than 1,600 follow-up financing rounds. The fund has also successfully sold shares in more than 100 companies.
Investors in the public-private partnership include the Federal Ministry of Economics and Energy, KfW Capital, the Fraunhofer-Gesellschaft and 32 companies. Our investors:
Further information is available at

High-Tech Gründerfonds Management GmbH
Dr. Fabian Mohr, Investment Manager
Phone: +49 228 82300 181

Stay up to date

Subscribe now and receive the latest press releases on investments and other news from High-Tech Gründerfonds. We inform you about important developments at HTGF and provide you with interesting news from our portfolio. Whether it’s a successful exit, a new exciting investment or HR news – you’ll be the first to know!

12. June 2024

New component for Germany’s Future Fund: HTGF Opportunity Fund launches with €660 million for growth-phase investments

Through the new fund, HTGF will be able to invest in selected HTGF portfolio companies. The objective of the HTGF Opportunity Fund is to increase the volume of later-stage financing rounds in the HTGF portfolio as required. Tenth Future Fund component added – another measure taken by the German government as part of its start-up strategy, helping to strengthen the country’s profile as a start-up hub. HTGF is one of Germany’s most active early-stage investors. Since its i
6. June 2024

SmartLoC secures 1.8 million Euros seed funding to revolutionize international trade payments

Hamburg, Germany – 6 June 2024 – SmartLoC, a pioneering startup focused on developing a cutting-edge, fully digital B2B payment solution based on the monitoring of shipments and specifically tailored for international trade, today announces the successful closure of its seed round, raising a total of 1.8 million euros. The round is led by High-Tech Gründerfonds (HTGF), one of the leading seed investors in Europe. Other investors include Loggerhead -Ventures, an early stage climatech VC