T-CURX acquires Pantherna Therapeutics to accelerate clinical translation of its non-viral in vivo CAR-T strategies

• T-CURX leverages Pantherna’s deep expertise and proprietary technologies in LNP-based delivery of mRNA and DNA vectors to advance T-CURX innovative in vivo CAR-T assets into clinical trials one year earlier
• T-CURX’ proprietary and clinically validated transposon-based non-viral CAR-T technology is potentiated and de-risked by Pantherna’s proprietary PTXmRNA® and PTX-DLNP® platforms, enabling the expansion of in vivo CAR-T therapies beyond cancer indications
• T-CURX’ acquisition of Pantherna builds on a successful prior technology collaboration and preclinical validation of their combined technologies

Today, leading CAR-T company T-CURX announces the signing of a definitive agreement for the acquisition of Pantherna Therapeutics, a German biotechnology company specializing in mRNA engineering and lipid nanoparticle (LNP) delivery technologies. Pantherna will continue to operate as Pantherna Therapeutics as a wholly owned subsidiary of T-CURX. The complementary expertises and proprietary technologies of both companies will be leveraged to accelerate clinical translation of CAR-T strategies with a clear focus on clinical validation of in vivo CAR-T therapies. T-CURX is a Würzburg-headquartered private biotech company with an additional site in Munich with strong expertise, proprietary technologies and track record for clinical translation of non-viral, transposon-based CAR-T therapies for novel and differentiated targets. T-CURX is backed by private investors and an international syndicate of blue-chip Biotech investors led by Swiss BiomedVC. T-CURX closed a USD 20.5 million Series A financing round at the end of 2025. Pantherna was supported by a group of private investors and Germany-based High-Tech Gründer Fonds (HTGF), who will become new shareholders of T-CURX. Financial terms of the transaction are not disclosed.

“With this acquisition, we are bringing together two highly complementary technology platforms and teams. We are taking a decisive step forward to accelerate the clinical development of differentiated, next-generation in vivo CAR-T therapies,” said Ulf Grawunder, CEO and co-founder of T-CURX. “Our strength in clinical translation of non-viral transposon-based CAR-T therapies combined with Pantherna’s proprietary mRNA and LNP-based delivery capabilities allows us to build an efficient engine to expedite clinical development of differentiated in vivo CAR-T assets in cancer, as well as in other indications.”

“Joining T-CURX is a natural evolution of our collaboration,” said Ansgar Santel, CEO of Pantherna Therapeutics. “This integration allows us to address both stable and transient cell engineering strategies based on powerful and proven proprietary platforms. We believe this positions us uniquely to efficiently drive CAR-T innovation forward for patients in need, particularly for in vivo CAR-T strategies across a broad range of therapeutic applications.”

The combination of both companies positions T-CURX to become a leading next-generation CAR-T player, being the first European Biotech with both proprietary CAR-T and LNP-technologies under one roof, allowing integration of key capabilities across the full value chain from discovery to clinical development of CAR-T products. Post acquisition, the company will have a total headcount of 35 and will manage a collective portfolio of currently 16 patent families protecting the combined technologies and assets.

About T-CURX

T-CURX GmbH is a private, Würzburg & Munich based, German biotech company with a wholly owned subsidiary, Pantherna Therapeutics, in Hennigsdorf & Berlin, Germany, combining next-generation non-viral CAR-T and LNP-nucleic acid vector delivery technologies under one roof. T-CURX is financially backed by a syndicate of international VC investors and family offices from Germany and Switzerland, led by Swiss BiomedVC, with Bayernkapital (Germany), Highlight Capital (China) and i&iBio Fund (Czech Republic) as institutional co-investors. T-CURX has the vision to bring innovative CAR-T cell therapies based on cost-effective and highly scalable non-viral ex vivo and in vivo CAR-T strategies to more cancer patients in need of these effective cancer therapies. T-CURX was spun out of the laboratory of T-CURX’s co-founder Prof. Michael Hudecek at the University of Würzburg and is led by Ulf Grawunder, PhD, a seasoned serial entrepreneur as CEO, who is also one of the co-founders. For more information about T-CURX, visit the company’s website at: www.t-curx.com

About Pantherna Therapeutics

Pantherna Therapeutics GmbH, a T-CURX company, is a biotech company from Hennigsdorf, Germany, with additional operations in Berlin, specializing in mRNA engineering and lipid nanoparticle (LNP) delivery technologies. Its proprietary PTXmRNA® and PTXΔLNP® platforms enable transient, controllable gene expression and targeted in vivo delivery of nucleic acids. Pantherna adds a crucial technology layer for potentiating T-CURX next-generation CAR-T therapies, further advancing ex vivo as well as future in vivo CAR-T strategies in oncology and also additional indications. For more information about Pantherna Therapeutics, visit the company’s website at www.pantherna-therapeutics.com