Neuromodulation pioneer WISE closes EUR 15M Series C financing round
to launch second product, SCS EXPERT, for chronic pain

October 1, 2020

  • SCS EXPERT – first expandable percutaneous lead for neuromodulation treatment of chronic pain
  • New investors, CDP Venture Capital and Eureka!, join existing participating investors in financing round
  • Adds to EUR 2.3M grant earlier in 2020 from the European Commission to launch SCS EXPERT

WISE Srl, a medical device company developing next-generation implantable leads for neuromonitoring, neuromodulation and brain-machine interfacing, today announced the closing of a EUR 15 million Series C financing round. New investors, led by CDP Venture Capital SGR, and including Indaco Ventures I Fund and EUREKA! Venture SGR, joined existing investors participating in this round – Principia SGR, New Frontier, Atlante Seed and Atlante Ventures (funds managed by Indaco Venture Partners SGR), High-Tech Gründerfonds and F3F.

The proceeds will be partially used to accelerate the development of the Company’s second product, SCS EXPERT (EXpandable PERcuTaneous), a percutaneously implantable multi-column paddle lead for Spinal Cord Stimulation (SCS). The funds will also support the upcoming launch of its first product, WISE Cortical Strip (WCS), a single use medical device for IntraOperative Neurophysiological Monitoring during brain tumor and epilepsy surgeries, which is anticipating the granting of its CE mark.

This financing adds to the recent European Commission grant of EUR 2.3 million given to WISE in July 2020, to support the development and launch of SCS EXPERT within the EIC Accelerator program of Horizon 2020.

We are delighted with the support we have received for our latest funding round and welcome our new investors. With this additional funding, we will be able to accelerate our plans to launch SCS EXPERT, as we make progress toward FDA clearance and market launch. With support from our engaged investors, we remain committed to build on our innovative drive and passion to provide the best lead with the least invasive implantation procedure to the SCS market; potentially bringing relief to patients suffering from chronic pain and other disorders.

Luca Ravagnan, CEO at WISE

Chronic pain is a debilitating disease for sufferers and treatment costs billions for the European and US healthcare systems each year. Globally, around 328 million people suffer from high-impact chronic pain – pain that lasts three months or longer and is accompanied by at least one major activity restriction.

To date, the therapeutic market has been dominated by drugs from several classes including non-steroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics. However, the increased scrutiny of opioid use worldwide has led to a significant rise in interest in alternative treatments, such as neuromodulation using SCS implants. The current neuromodulation market has an estimated value of $5.8 billion, with over 50% of the value given by the SCS sector.

SCS implants work by blocking pain signals before they reach the brain through the delivery of electrical stimuli to the spinal cord by means of implantable leads.  Currently there are two types of implantable leads available – multi-column paddle leads and cylindrical leads. Multi-column paddle leads offer better overall treatment results, but current products can only be inserted surgically

Thanks to its proprietary SCBI technology, WISE is the first company capable of producing a multi-column paddle lead – the SCS EXPERT – that can be folded in a catheter and implanted percutaneously like a cylindrical lead, i.e. with no surgical intervention required. This will offer the opportunity to the patient for the first time to receive the best SCS lead with the least invasive implantation procedure.

We are delighted to support WISE’s brilliant team in this important phase. The technological advantage deriving from the unique characteristics of the proprietary technologies underlying its medical leads has been validated with the first product, WISE Cortical Strip. We are confident this will be a distinctive feature also of SCS EXPERT, thus confirming the enormous potential that WISE has in its ability to offer cutting edge solutions to unmet medical needs, hence to improve quality of life of millions of people.

Laura Scaramella from CDP Venture Capital SGR S.p.A.

We are very pleased to continue our journey towards market entry together with WISE and our fellow shareholders.  The technology is combining the best of both worlds, using minimal invasive procedures to implant multi-column leads. This has the potential to revolutionize the growing neuromodulation market valued at $5.8 billion and improve the treatment results of millions of chronic pain patients.

Kay Balster Principal, High-Tech Gründerfonds

About WISE Srl
WISE has developed a genuinely new generation of leads for neuromonitoring, neuromodulation and brain machine interfacing by means of its proprietary Supersonic Cluster Beam Implantation (SCBI) technology.
Neuromonitoring and neuromodulation require electrodes and leads to be surgically implanted on neural tissues (as for instance the brain and the spinal cord) to apply electrical stimuli or to record the electrical activity. The leads produced using WISE’s new SCBI technology consist of stretchable electronic circuits integrated in very thin elastomeric foils. As a result, WISE’s electrodes are highly ergonomic, conformable, soft and thin, thus allowing great adhesion, minimal invasiveness and excellent adaptability on neural tissues.
In parallel with the development of the SCS EXPERT lead, WISE will be soon launching the WISE Cortical Strip (WCS), a single use medical device for IntraOperative Neurophysiological Monitoring during brain tumor and epilepsy surgeries. The WCS is used for continuous recording of the brain’s electrical activity and for brain stimulation. The Company has applied for its CE mark.
Founded in 2011 by a team of material scientists coming from the University of Milan, WISE has so far received funding from Agite!, Atlante Seed and Atlante Ventures, b-to-v, HTGF, Principia SGR, New Frontier and private investors, and closed a Series C funding round in 2020 with new investors (CDP Venture Capital SGR S.p.A. and Eureka! Venture SGR S.p.A). In 2016, the Company established its production plant in Cologno Monzese, Milan, Italy (1000 m2 wide, comprising cleanrooms and production laboratories compliant for the manufacturing of implantable medical devices) and has an office in Berlin, Germany.
For more information, please visit:

Dr. Luca Ravagnan, CEO
+39 02 84962493
Instinctif Partners for WISE Srl
Melanie Toyne-Sewell / Agnes Stephens / Kiki Zaccagnini

About CDP Venture Capital SGR S.p.A.
CDP Venture Capital – Fondo Nazionale Innovazione aims to make Venture Capital a strategic pillar to Italy’s economic growth and innovation, creating the conditions for a comprehensive and sustainable growth of the Italian Venture Capital ecosystem.

About EUREKA! Venture SGR  S.p.A.
EUREKA! Venture SGR manages Eureka! Fund I – Technology Transfer”: investments are focused on proof of concept, seed and early stage deals in spinoffs and startups steaming out from Italian Universities and Research Centers. Ideas and companies backed by Eureka! Fund has a competitive advantage stems from cutting-edge proprietary technologies and innovations with a clear and unique vision on intellectual property rights.

About Principia SGR
Principia SGR is one of the leading Italian venture capital firms. Currently the company manages three investment funds, called Principia Fund, Principia Principia II and III – Health. Through the first two funds – today fully invested – Principia has funded about 40 companies in the start-up phase and by supplying growth capital. Principia III-Health has announced a first closing at EUR 160 millions in August 2014. Principia III – Health is the first Venture Capital and Growth Capital fund in Italy specifically dedicated to the healthcare sector. The fund plans to invest in start-up and early-stage companies as well as small and medium sized (SME) companies. Goal is to contribute to the development of a sector in Italy that is characterized by the presence of high skills and internationally recognized quality but suffers currently from the lack of financial support.  For more information, please visit:

About New Frontier S.p.A.
Located in Padua (Italy), New Frontier is a privately-owned Italian company focused on investments in innovative enterprises. Amigdala invests in start-up and early-stage companies with a high growth potential, with a particular focus on Italian companies in the bio-tech industry.

About Indaco Venture Partners SGR
Founded in 2016, today Indaco Venture Partners SGR is the largest independent Italian venture capital asset management company, with a strong specialization in companies that innovate in electronics and robotics, medtech, digital and new materials. Indaco manages over 250 million across its five funds.

About F3F
F3F is an Italian company controlled by biotech and healthcare entrepreneur Laura Iris Ferro. Based in Milan the company has an investment policy aimed at taking stakes in diversified business with high return potential including traditional ones as real estate and innovative ones such as life science.

About High-Tech Gründerfonds
High-Tech Gründerfonds (HTGF) is a seed investor that finances high-potential, tech-driven start-ups. With around EUR 900 million in total investment volume across three funds and an international network of partners, HTGF has already helped forge almost 600 start-ups since 2005. Driven by their expertise, entrepreneurial spirit and passion, its team of experienced investment managers and startup experts help guide the development of young companies. HTGF’s focus is on high-tech start-ups in the fields of digital tech, industrial technology, life sciences, chemistry and related business areas. To date, external investors have injected over EUR 2.6 billion into the HTGF portfolio via more than 1,600 follow-on financing rounds. HTGF has also successfully sold interests in more than 100 companies.

Investors in the public-private partnership include the Federal Ministry of Economics and Energy, KfW Capital, the Fraunhofer-Gesellschaft and 32 companies. Our Fund Investors

High-Tech Gründerfonds Management GmbH
Kay Blaster, Investment Manager – Principal
T.: +49 228 82300 111

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